Costello and Gwilliam developed a systematic approach to perturbative quantization of field theories that describes classical and quantum observables as factorization algebras on the space-time manifold. In the simple case of the linear sigma model whose fields are smooth maps from the real line to an inner product space $V$ (aka the free boson), the algebra of quantum observables is the Weyl algebra of differential operators on $V$. For the free fermion, where $V$ is replaced by its odd analog, the algebra of quantum observables is the Clifford algebra generated by $V$.
Links:
[1] https://www.mpim-bonn.mpg.de/de/taxonomy/term/39
[2] https://www.mpim-bonn.mpg.de/de/node/3444
[3] https://www.mpim-bonn.mpg.de/de/node/13069